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A Simple PBPK Model

PK-Sim/OSP-Suite Version 11

Length: 6 Check-Up-Points

Regular price 400,00 €
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In this series of exercises, you will learn how to create a PBPK model of midazolam, a widely used sedative, approved as premedication before surgical interventions. More specifically you learn how to:

1. Utilize in vitro data
2. Perform sensitivity analysis of the model
3. Optimize the model with parameter identification
4. Compare simulation results with observed data

The exercises are based on the published PBPK model of midazolam:
Hanke N. et al. CPT Pharmacometrics Syst. Pharmacol. (2018) 7, 647–659