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Workshop Day 3 (PAGE 2025)

Workshop Day 3 (PAGE 2025)

OSP-Suite/Event

Daios Luxury Living Hotel, Leof. Nikis 59, Thessaloniki 546 22, Greece
June 07, 2025
9:00 am - 5:00 pm

Modular PBPK Modeling and Quality-Controlled Simulation Workflows in R with OSP Suite V12 (Use Case: Pregnancy PBPK)

Join us for our third Satellite Workshop of the week!

Summary: 

This full-day workshop offers a powerful combination of hands-on modular customized PBPK(-QSP) modeling and quality-controlled simulation workflows in R, leveraging the latest advancements in OSP Suite V12. 

🔹 Part 1: Modular PBPK Modeling in OSP Suite V12 
Participants will explore the new modularization framework in PK-Sim and MoBi, learning how to extend a PBPK model with a pregnancy module to simulate fetal drug exposure. ESQlabs instructors will guide attendees through: 

  • Seamlessly adding a pregnancy module to an existing PBPK model.
  • Incorporating protein expression data for mechanistic refinements.
  • Simulating individual variability using MoBi’s new features. 

🔹 Part 2: Quality-Controlled M&S Projects in R with {esqlabsR} 
The second half of the workshop focuses on streamlining PBPK-QSP modeling workflows in R using {esqlabsR}, a package designed to enhance reproducibility, transparency, and automation. Participants will: 

  • Set up and execute simulation scenarios efficiently.
  • Generate standardized figures for results visualization.
  • Perform sensitivity analyses to assess parameter impact.
  • Automate reporting using Markdown templates for regulatory-compliant documentation. 

Agenda Highlights: 

  • Modularization in OSP Suite V12 
  • Pregnancy modeling and fetal exposure simulation 
  • {esqlabsR} for structured, reproducible M&S workflows 
  • Running and analyzing customized PBPK(-QSP) simulation scenarios 
  • Automated sensitivity analysis and visualization 
  • Generating standardized reports in R 

Who Should Attend? 

This workshop is ideal for PBPK/QSP modelers, pharmacologists, and regulatory scientists looking to learn about modular customized PBPK(-QSP) modeling in OSP Suite V12 and implement quality-controlled simulation workflows in R. Attendees will leave with practical, hands-on experience in modularization, scenario execution, and automated reporting, essential for regulatory-compliant customized PBPK(-QSP) modeling. 

Instructors: Pavel Balazki and Nina Nauwelaerts  

The workshop fee includes catering and access to our training materials.

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