Workshop 1 (PAGE 2024)

OSP Suite (PK-Sim®, MoBi®) WORKSHOP 1: Biologics (ADC) PBPK/PD and Small Molecule DDI

esqLABS will provide hands-on training on the most sought-after topics in physiologically-based pharmacokinetic (PBPK) and quantitative systems pharmacology (QSP) modeling using PK-Sim® and MoBi® (OSP-Suite). The first workshop will cover practices for protein/antibody PBPK and PD modeling for antibody-drug-conjugates (ADCs) for the treatment of tumor growth accounting for target-mediated drug disposition (TMDD). In the afternoon, it will provide an in-depth training on how to leverage the OSP-Suite Software and Model Library for PBPK-based assessments of drug-drug interactions (DDI).

Learning objectives:

1. Develop, extend, and customize PBPK models with a focus on biologics to simulate disease mechanisms and drug effects (PBPK/PD or PBPK-QSP models) using PK-Sim® and MoBi®.
   1. Gain experience with hands-on exercises with a protein/antibody PBPK model for ADCs for the treatment of tumor growth accounting for TMDD
2. Explore how to simulate the PK of a drug and its metabolite and the metabolizing enzyme for DDI.
   1. Learn how to work with the OSP Suite Model Template Database
   2. Learn how to define Parent-Metabolite and Drug-Interaction kinetics
   3. Learn about regulatory requirements for the execution and reporting of PBPK-based DDI assessments

While the workshop does not require prior experience with PK-Sim® and MoBi®, many topics will interest even advanced users.

Agenda

The workshop will be held on June 24  from 9:00 a.m. to 5:00 p.m. The agenda can be found in the Image Gallery.

Workshop Material

Industry Professionals will receive a new or updated account with all the relevant hands-on courses with free access.

Academia and Students get free access to the course material in our e-learning platform: Academic Learning Center.

Cancellation Policy

Cancellation will be compensated in the form of esqLABS training course vouchers at the same value.

Preparation

You will need your laptop with the following software pre-installed:

• To download the software version 11, please click here
• Download & install the R distribution (Ver 4.0+) from here
• Download & install FREE RStudio Desktop (a GUI for R with additional functionalities for e.g., debugging and code visualization) from here

Location

The location will either be the conference hotel or a hotel in its vicinity.

Workshop Instructors

• Dr. Stephan Schaller (CEO and Lead Scientist)
• Dr. Wilbert De Witte (Principal Scientist)
• Pavel Balazki (Software Lead)

FREE VOUCHER

The registered participants will be given a free voucher to access our upcoming course on OSP R & esqlabsR frameworks! More about them here.

NEED AN INVOICE?

After filling out the personal information required to run the workshop, you will be directed to the Checkout. Please select the Bank deposit option and write down the billing details. You will receive an Invoice (PDF) automatically, and we will fulfill the order once we receive the payment.

Please make sure to arrange it prior to the event to avoid any additional costs for issuing the invoice manually by us.

Please contact training@esqlabs.com if you experience any problems.